Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) | PAS 22 096

Opportunity Information: Apply for PAS 22 096

The Stimulating Hematology Investigation: New Endeavors (SHINE) program is an NIH funding opportunity designed to grow and strengthen the nonmalignant hematology research space by encouraging innovative, high-quality projects that fit the missions of three participating NIH Institutes: the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). The mechanism is an investigator-initiated R01 research project grant, and it is focused on basic research and early translational research rather than later-stage clinical testing. As stated in the title, clinical trials are not allowed under this announcement, which generally signals that the proposed work should not involve prospective assignment of human participants to an intervention with the goal of evaluating health-related outcomes, even if the study is relatively small or exploratory. In practical terms, the FOA is meant to catalyze new directions, new investigators, and new lines of inquiry in nonmalignant blood science, with an emphasis on creativity and strong scientific rationale.

A distinctive feature of SHINE is that the program highlights "emerging topics" in hematology that are considered leading edge, but it does not treat that list as static. Instead, the specific scientific topics of interest are expected to evolve as the field moves, and NIH updates these areas on an annual basis through notices in the NIH Guide to Grants and Contracts, with those updates linked back to the funding opportunity announcement (FOA). This structure is meant to keep the program responsive to advances in biology, technology, and translational opportunities, and it encourages applicants to align their R01 proposals with the most current set of targeted or emphasized research directions without locking the program into a single fixed roadmap for multiple years.

The opportunity is categorized as a discretionary grant program administered by the National Institutes of Health, with activity aligned to health (and listed under the broad activity category of Food and Nutrition, Health). The Funding Opportunity Number is PAS-22-096, and the corresponding CFDA (assistance listing) numbers provided are 93.847 and 93.866. While the source information does not specify an award ceiling or the expected number of awards, applicants should typically rely on the full FOA text and NIH standard R01 policies for budget structure, project period expectations, and any institute-specific considerations, since those details are often governed by NIH-wide rules plus institute-level budget guidance.

Eligibility is broad and includes many standard NIH-eligible organization types across the public, private, nonprofit, and for-profit spectrum. Eligible applicants listed include state, county, and local governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations other than federally recognized tribal governments. Nonprofits are eligible whether or not they hold 501(c)(3) status, and for-profit organizations other than small businesses are also eligible, along with small businesses. The announcement also explicitly calls out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. This breadth signals an intent to attract strong ideas from a wide range of institutions and communities, including organizations that may be underrepresented in certain research portfolios.

At the same time, the FOA places clear boundaries on foreign involvement. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed, which typically means a U.S.-based applicant may include a justified portion of the work to be performed outside the U.S. when it is scientifically necessary and appropriately documented, subject to NIH rules and approvals. This approach allows applicants to access unique expertise, populations, specimens, or technologies abroad when needed, while keeping the prime award anchored at an eligible U.S. institution.

Key administrative details in the provided source include an original closing date of 2025-01-07 and a creation date for the record of 2021-12-22. Overall, SHINE is positioned as a growth-oriented R01 program for nonmalignant hematology that prioritizes innovation, basic and early translational impact, and alignment with a set of cutting-edge topic areas that NIH refreshes regularly to reflect where the science is headed.

• The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847, 93.866.
• This funding opportunity was created on 2021-12-22.
• Applicants must submit their applications by 2025-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAS 22 096

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: