Opportunity Information: Apply for PA 18 380
Family-Centered Self-Management of Chronic Conditions (R21 Clinical Trial Optional) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PA 18 380; CFDA 93.361) designed to strengthen the research base for family-centered self-management (FCSM) in the context of chronic health conditions. The core idea behind the announcement is to move beyond self-management approaches that focus only on the individual patient and instead generate evidence about how families, caregivers, and broader family systems can be intentionally engaged to improve the day-to-day management of long-term illness. In practical terms, the FOA supports studies that help define, test, refine, or otherwise advance the science of how family involvement influences adherence, symptom monitoring, lifestyle adjustments, treatment decision-making, and long-term functioning for people living with chronic conditions.
The funding mechanism is an R21, which typically supports early-stage, exploratory, or developmental research. That makes this opportunity a fit for projects that are building preliminary evidence, developing and piloting interventions, testing key concepts or measures, or establishing feasibility for larger future trials. The notice also states that a clinical trial is optional, meaning applicants may propose either clinical trial work (for example, a pilot intervention study with human participants) or non-trial research (such as intervention development, observational research, or measurement/implementation groundwork), as long as the project clearly contributes to building FCSM science in chronic disease contexts.
The maximum award amount listed is an award ceiling of $200,000, signaling that projects should be scoped to produce meaningful, targeted advances rather than large, multi-site definitive trials. While the source snippet does not specify the exact number of expected awards, the intent is clearly to stimulate a pipeline of studies that can later support larger-scale research and broader implementation. The activity categories associated with the opportunity are Education and Health, reflecting the intersection of health behavior, caregiving dynamics, patient and family education, and health outcomes in chronic illness management.
Eligibility is broad and includes a wide range of public, private, nonprofit, and governmental entities. Eligible applicants explicitly include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (other than small businesses); and small businesses. In addition, the FOA highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISI); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; tribal governments other than federally recognized entities; and non-U.S. (foreign) organizations. This breadth suggests an emphasis on encouraging diverse institutional participation and supporting research that is relevant across different communities and care settings.
Key administrative details provided include an original closing date of January 7, 2021, and a creation date for the opportunity record of November 21, 2017. As written, this indicates the announcement was open during that period and may now be expired or superseded by a reissued NIH notice, but the summary purpose and structure remain useful for understanding what NIH sought to fund under PA 18 380: research that advances the evidence, methods, and conceptual foundations for family-centered approaches to chronic condition self-management, with flexibility to include clinical trial elements when appropriate.Apply for PA 18 380
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Family-Centered Self-Management of Chronic Conditions (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361.
- This funding opportunity was created on 2017-11-21.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Family-Centered Self-Management of Chronic Conditions (R21 Clinical Trial Optional).
Which agency is offering this grant?
This is a discretionary grant opportunity from the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number listed is PA 18 380.
What is the CFDA number for this opportunity?
The CFDA number provided is 93.361.
What is the main purpose of the FOA?
The FOA is designed to strengthen the research base for family-centered self-management (FCSM) in chronic health conditions by generating evidence on how families and caregivers can be intentionally engaged to improve day-to-day management of long-term illness.
What does “family-centered self-management (FCSM)” mean in this context?
In this FOA, FCSM refers to approaches that go beyond focusing only on the individual patient and instead examine how families, caregivers, and broader family systems influence self-management behaviors and outcomes for people living with chronic conditions.
How is this different from traditional self-management research?
Traditional self-management approaches often focus on the patient alone. This FOA emphasizes generating evidence about how family involvement affects key aspects of chronic disease management (for example, adherence and symptom monitoring) and how family systems can be engaged as part of the solution.
What types of chronic-condition management topics are in scope?
The FOA highlights research related to how family involvement influences items such as adherence, symptom monitoring, lifestyle adjustments, treatment decision-making, and long-term functioning for people living with chronic conditions.
What grant mechanism is used for this opportunity?
The funding mechanism is an R21.
What kind of projects typically fit an R21 mechanism?
As described, the R21 mechanism typically supports early-stage, exploratory, or developmental research. This can include building preliminary evidence, developing and piloting interventions, testing key concepts or measures, or establishing feasibility for later, larger studies.
Are clinical trials required under this FOA?
No. The FOA states that a clinical trial is optional. Applicants may propose either clinical trial work or non-trial research, as long as the project advances FCSM science in chronic disease contexts.
If clinical trials are optional, what kinds of non-trial studies could fit?
The FOA indicates that non-trial research may include items such as intervention development, observational research, or measurement/implementation groundwork, provided it clearly contributes to building the science of family-centered self-management.
What kinds of clinical trial work could fit if an applicant chooses to include it?
The FOA gives an example of clinical trial work as a pilot intervention study with human participants. The overall intent is exploratory or developmental work appropriate for an R21.
What is the maximum award amount?
The FOA lists an award ceiling of $200,000.
What does the $200,000 award ceiling imply for project scope?
Based on the description, the ceiling suggests projects should be scoped to deliver meaningful, targeted advances in FCSM science rather than large, definitive multi-site trials.
Does the information provided specify how many awards NIH expects to make?
No. The provided summary notes that the snippet does not specify the exact number of expected awards, but it describes an intent to stimulate a pipeline of studies that can later support larger-scale research and implementation.
What activity categories are associated with this opportunity?
The activity categories listed are Education and Health.
Who is eligible to apply?
Eligibility is described as broad, including many types of public, private, nonprofit, and governmental entities, along with for-profit organizations and small businesses.
Are state and local governments eligible?
Yes. Eligible applicants explicitly include state, county, city, township, and special district governments, as well as independent school districts.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and tribal organizations that are not federally recognized. The summary also lists tribal governments other than federally recognized entities as additional eligible applicant types.
Are nonprofits eligible to apply?
Yes. The FOA includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories, as stated in the description).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations (other than small businesses) and also separately includes small businesses.
Are housing authorities eligible?
Yes. The eligibility list includes public housing authorities and Indian housing authorities.
Are minority-serving institutions specifically included?
Yes. The FOA highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly lists faith-based or community-based organizations among additional eligible applicant types.
Are federal agencies eligible to apply?
Yes. The FOA includes eligible federal agencies.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicant types.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA includes non-U.S. (foreign) organizations.
What is the closing date shown for this opportunity?
The key administrative details provided include an original closing date of January 7, 2021.
What is the creation date shown for this opportunity record?
The opportunity record creation date provided is November 21, 2017.
Is this opportunity likely still open?
Based on the dates provided (closing date of January 7, 2021), the summary indicates the announcement may now be expired or superseded by a reissued NIH notice, even though the purpose and structure remain useful for understanding what NIH sought to fund under PA 18 380.
What overall impact is NIH trying to achieve with this FOA?
The FOA aims to build evidence, methods, and conceptual foundations for family-centered approaches to chronic condition self-management, supporting studies that can help establish a stronger pipeline for future, larger-scale research and broader implementation.
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| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Clinical Trial Required) Apply for PA 18 393 Funding Number: PA 18 393 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Healthy Habits: Timing for Developing Sustainable Healthy Behaviors in Children and Adolescents (R21 Clinical Trial Optional) Apply for PA 18 354 Funding Number: PA 18 354 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Healthy Habits: Timing for Developing Sustainable Healthy Behaviors in Children and Adolescents (R01 Clinical Trial Optional) Apply for PA 18 355 Funding Number: PA 18 355 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Tobacco Use and HIV in Low and Middle Income Countries (R01 Clinical Trial Optional) Apply for PAR 18 023 Funding Number: PAR 18 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Tobacco Use and HIV in Low and Middle Income Countries (R21 Clinical Trial Optional) Apply for PAR 18 022 Funding Number: PAR 18 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R01 Clinical Trial Optional) Apply for PAR 18 246 Funding Number: PAR 18 246 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Evaluating the NIDA Standardized Research E-Cigarette in Risk Reduction and Related Studies (U01 Clinical Trial Optional) Apply for PAR 18 220 Funding Number: PAR 18 220 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Predicting Behavioral Responses to Population-Level Cancer Control Strategies (R21 Clinical Trial Optional) Apply for PAR 18 024 Funding Number: PAR 18 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Intervening with Cancer Caregivers to Improve Patient Health Outcomes and Optimize Health Care Utilization (R21 Clinical Trial Optional) Apply for PAR 18 247 Funding Number: PAR 18 247 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R01 Clinical Trial Optional) Apply for PA 18 274 Funding Number: PA 18 274 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Quantitative Imaging Tools and Methods for Cancer Therapy Response Assessment (UG3/UH3 Clinical Trial Optional) Apply for PAR 18 248 Funding Number: PAR 18 248 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Innovations in Mechanisms and Interventions to Address Mental Health in HIV Prevention and Care Continuum (R21 Clinical Trial Optional) Apply for PA 18 275 Funding Number: PA 18 275 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Increased Knowledge and Innovative Strategies to Reduce HIV Incidence-iKnow Projects (R01 Clinical Trial Optional) Apply for PAR 18 254 Funding Number: PAR 18 254 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional) Apply for PAR 18 189 Funding Number: PAR 18 189 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional) Apply for PAR 18 190 Funding Number: PAR 18 190 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01 Clinical Trial Optional) Apply for PA 18 279 Funding Number: PA 18 279 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R21 Clinical Trial Optional) Apply for PA 18 280 Funding Number: PA 18 280 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Quantitative Imaging Tools and Methods for Cancer Response Assessment (U01 Clinical Trial Optional) Apply for PAR 18 249 Funding Number: PAR 18 249 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Health Services Research on Minority Health and Health Disparities (R01 Clinical Trial Optional) Apply for PAR 18 286 Funding Number: PAR 18 286 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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