Opportunity Information: Apply for PAR 18 845
The grant opportunity titled "Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed)" (Funding Opportunity Number PAR-18-845) is a discretionary NIH research grant designed to fund basic, mechanistic studies on how aerosols produced by electronic nicotine delivery systems affect biological systems. The central focus is on understanding what ENDS aerosols do to human-relevant cells, tissues, and organs, both under normal conditions and in the context of disease states. In practical terms, the program is aimed at foundational science: identifying biological pathways, cellular responses, tissue-level changes, and organ-specific mechanisms that are triggered or altered by exposure to ENDS aerosols or their constituents. Because it is an R01 mechanism, the opportunity is geared toward well-developed, hypothesis-driven projects that can support a sustained, multi-year line of investigation rather than short pilot work.
A key feature of this announcement is that clinical trials are not allowed. That means applicants are expected to stay within the boundaries of basic or preclinical research rather than testing interventions or outcomes in a way that meets the definition of a clinical trial. Typical approaches under this kind of announcement would include in vitro studies using human or animal cells, ex vivo models, organoids, tissue explants, and in vivo animal models, as well as advanced analytical and toxicological methods that can clarify dose-response relationships and mechanisms of action. The emphasis on "basic mechanisms" signals that descriptive studies are generally less competitive unless they clearly connect to mechanistic questions, such as identifying causal pathways, biomarkers linked to exposure, or specific constituents that drive harmful or adaptive responses.
The sponsoring agency is the National Institutes of Health, and the program is associated with multiple CFDA numbers (93.113, 93.121, 93.279, 93.399), reflecting that the topic spans more than one NIH institute or center mission area. The funding instrument is a grant, and the activity categories listed include education, environment, and health, which aligns with the cross-cutting nature of ENDS research: aerosol exposures intersect environmental exposure science and toxicology, while outcomes and mechanisms relate to respiratory, cardiovascular, immune, neurological, and other health domains. The source information lists an original closing date of June 15, 2021 and a creation date of June 29, 2018. No award ceiling or expected number of awards is specified in the provided data, which usually means budgets and award counts may depend on NIH institute participation, application volume, and available appropriations in a given cycle.
Eligibility is broad and includes most common U.S. applicant types: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also explicitly highlights additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). Taken together, this indicates NIH is encouraging a wide range of research performers and perspectives, including institutions serving underrepresented populations and organizations located outside the continental U.S., to contribute to the evidence base on ENDS aerosol health effects.
Overall, this opportunity is best understood as NIH support for rigorous laboratory and mechanistic research that can clarify how ENDS aerosol exposure translates into biological changes relevant to human health and disease. The scientific payoff NIH is seeking is the kind of foundational understanding that can later inform risk assessment, regulatory science, product standards, and future applied or clinical research, without directly conducting clinical trials under this particular funding announcement.Apply for PAR 18 845
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.279, 93.399.
- This funding opportunity was created on 2018-06-29.
- Applicants must submit their applications by 2021-06-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (PAR 18 845) also looked into and applied for these:
| Funding Opportunity |
|---|
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R21 - Clinical Trial Not Allowed) Apply for PAR 18 846 Funding Number: PAR 18 846 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 18 002 Funding Number: RFA ES 18 002 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $1,750,000 |
| Emerging Global Leader Award (K43 Independent Clinical Trial Required) Apply for PAR 19 038 Funding Number: PAR 19 038 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01 Clinical Trial Not Allowed) Apply for PAR 19 039 Funding Number: PAR 19 039 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $300,000 |
| Countermeasures Against Chemical Threats (CounterACT): Optimization of Therapeutic Lead Compounds (U01 Clinical Trial Optional) Apply for PAR 19 040 Funding Number: PAR 19 040 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Promoting Research on Music and Health: Fundamentals and Applications (R21 Clinical Trials Optional) Apply for RFA NS 19 009 Funding Number: RFA NS 19 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Immuno-Oncology Translation Network (IOTN): Cancer Immunoprevention Research Projects (UG3/UH3) Apply for RFA CA 19 012 Funding Number: RFA CA 19 012 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Emerging Global Leader Award (K43 Independent Clinical Trial Required) Apply for PAR 19 051 Funding Number: PAR 19 051 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 19 055 Funding Number: PA 19 055 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed) Apply for PA 19 053 Funding Number: PA 19 053 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 19 054 Funding Number: PA 19 054 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 19 052 Funding Number: PA 19 052 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $50,000 |
| NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 19 091 Funding Number: PA 19 091 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 19 092 Funding Number: PA 19 092 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 088 Funding Number: PA 19 088 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed) Apply for PAR 19 098 Funding Number: PAR 19 098 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 19 121 Funding Number: PA 19 121 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 19 122 Funding Number: PA 19 122 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 19 131 Funding Number: PA 19 131 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 19 132 Funding Number: PA 19 132 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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